髓鞘少突胶质细胞糖蛋白为风疹病毒的细胞受体

2012-02-14 20:30 来源:丁香园 作者:北京中国科学院病原微生物与免疫学重点实验室
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J Virol 2011 Nov;85 (21): 11038-47. [IF:5.189]
Identification of the myelin oligodendrocyte glycoprotein as a cellular receptor for rubella virus.
Cong H , Jiang Y , Tien P .
Center for Molecular Virology, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China.
北京中国科学院病原微生物与免疫学重点实验室

Abstract
Rubella virus (RV) is a highly transmissible pathogenic agent that causes the disease rubella. Maternal RV infection during early pregnancy causes the death of the fetus or congenital rubella syndrome in infants. However, the cellular receptor for RV has not yet been identified. In this study, we found that the myelin oligodendrocyte glycoprotein (MOG) specifically bound to the E1 envelope glycoprotein of RV, and an antibody against MOG could block RV infection. Most importantly, we also showed that ectopic expression of MOG on the cell surface of 293T cells rendered this nonpermissive cell line permissive for RV entry and replication. Thus, this study has identified a cellular receptor for RV and suggests that blocking the MOG attachment site of RV may be a strategy for molecular intervention of RV infection.

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