一个难民，耐药和游击战争的故事
泰国Shoklo疟疾研究机构（SMRU）将于12月28日在Mae Sot 举办一次名为“疟疾研究之二十年：成就和展望”的科学论坛，本次论坛将有国际知名专家参加，并且将以交流和讨论众多与疟疾相关的话题为主要内容，涉及面从流行病学到治疗学，从免疫性到社会经济学。
SMRU位于泰国的Mae Sot ，毗邻缅甸，由于是第二十周年庆典，SMUR领导人Fran鏾is Nosten 教授将反映这一机构成功的历程。这一机构成立于地方难民营之中。目前推荐的疟疾疗法（基于含青蒿素衍生物的联合用药）是SMRU研究的结果，这也是泰国惠康信托主要海外项目的一部分。Nosten教授是疟疾研究中被引用最多的十位研究者之一，并且是抗寄生虫耐药株研究中的重要人物。
1896年SMRU在Nosten教授的家中开业，1989年这一研究机构移至Shoklo，这也是泰缅边境上最大的难民营，有9000名从边境上逃来的克伦族难民得到安置。这个研究机构的重点是研究孕妇和儿童中疟疾药物治疗的有效性。
这一机构于1996年被迫迁移至现在的住址Mae Sot，一年后，民主克伦族佛教军针对外国援助人员，企图迫使难民返回缅甸，他们受到了游击队的袭击。在这次袭击中，Nosten教授和他的同事Rose McGready被迫躲藏在丛林中。
目前，Nosten教授的工作得到了这个地区泰国民众的支持，包括许多当地克伦族和缅甸人士，这些人都曾接受过SMRU小组的培训。除了研究孕妇疟疾药物治疗，这个机构还开展青蒿素联合治疗的关键研究，目的是与迅速增长的耐药性作斗争。这个机构已经着手进行最大范围的疟疾药物试验和研究，并且影响着WHO对疟疾药物治疗指导方案的修改。
随着疟疾病例数的减少，这一机构的焦点已经转向其它健康问题，比如呼吸道疾病。此外，建立于1995年的监测网络可以监测沿边境的难民营中的疟疾感染，并且已经收到追踪禽流感病毒发展基金的资助。
http://www.eurekalert.org/pub_releases/2006-11/wt-tyo112006.php
Twenty Years of Malaria Research: Outcomes and Perspectives
A story of refugees, drug-resistance and guerrilla attacks
The Shoklo Malaria Research Unit (SMRU), Thailand, will be hosting a scientific seminar in Mae Sot on 28 December entitled "Twenty Years of Malaria Research: Outcomes and Perspectives" attended by internationally-renowned experts and featuring talks and debates on a variety of topics related to malaria, from epidemiology to therapeutics and from immunity to socio-economics.
As the Shoklo Malaria Research Unit (SMRU) in Mae Sot, Thailand, which borders Burma, celebrates its twentieth anniversary, its Director, Professor Fran鏾is Nosten, is able to reflect on the success of the unit, which is based amongst the region's refugee camps. The currently recommended malaria therapies (based on drug combinations including an artemisinin derivative) are the result of research carried out at SMRU, which is part of the Wellcome Trust's Major Overseas Programme in Thailand. Professor Nosten is amongst the top ten most-cited researchers in malaria research and has been a key player in the fight against drug-resistant strains of the parasite.
Opening in 1986 at Nosten's home, the research unit moved to Shoklo in 1989, the largest of the refugee camps on the border of Thailand and Burma, where 9,000 Karen refugees from across the border were housed. The focus of the research was to study the efficacy of malaria drug treatments in pregnant women and in children.
The unit was forced to move to its current location in Mae Sot in 1996 one year after an attack by guerrillas from the Democratic Karen Buddhist Army, targeting foreign aid workers in an attempt to force the refugees to return to Burma. During the attack, Professor Nosten and his colleague Rose McGready had been forced to hide in the jungle.
Now, Professor Nosten is assisted in his work by Thai nationals from the region, including a number of local Karen and Burmese who received training by the SMRU team. In addition to studying malaria drug treatments for pregnant women, the unit has carried out crucial research into artemisinin combination therapies (ACTs) aimed at combating the rapid rise in drug-resistance. The unit has carried out the largest number of drug trials in malaria and research at the unit has been influential in changing WHO guidelines for malaria drug treatment.
The reduction in the number of malaria cases has allowed the unit to focus on other health issues such as respiratory diseases. In addition, a surveillance network established in 1995 to monitor malaria infection in the camps along the border has now received funding to track the development of the avian influenza virus.
编辑：蓝色幻想
