Emerg Infect Dis 2011 Oct;17 (10): 1824-30. [IF:6.859]
Pandemic (H1N1) 2009 among quarantined close contacts, Beijing,
People's Republic of China.
Pang X , Yang P , Li S , Zhang L , Tian L , Li Y , Liu B , Zhang Y , Liu B , Huang R , Li X , Wang Q .
Beijing Center for Disease Prevention and Control, Beijing, People's Republic of China.
北京疾病预防控制中心
Abstract
We estimated the attack rate of pandemic (H1N1) 2009 and assessed risk factors for infection among close contacts quarantined in Beijing, People's Republic of China. The first 613 confirmed cases detected between May 16 and September 15, 2009, were investigated; 7,099 close contacts were located and quarantined. The attack rate of confirmed infection in close contacts was 2.4% overall, ranging from 0.9% among aircraft passengers to >5% among household members. Risk factors for infection among close contacts were younger age, being a household member of an index case-patient, exposure during the index case-patient's symptomatic phase, and longer exposure. Among close contacts with positive test results at the start of quarantine, 17.2% had subclinical infection. Having contact with a household member and younger age were the major risk factors for acquiring pandemic (H1N1) 2009 influenza virus infection. One person in 6 with confirmed pandemic (H1N1) 2009 was asymptomatic.
摘要
我们评估了中国北京2009年流行性H1N1流感的患病率以及被隔离的H1N1流感密切接触者的感染危险因子。2009年5月16日到9月15日期间，对最早被确诊的613例HIN1流感病例进行研究，并就地隔离了7099名密切接触者。在全部密切接触者中，确诊感染率为2.4%；从患病率来看，飞机乘客为最低的0.9%，家庭成员为最高，超过了5%。较低的年龄，“索引患者”（所知的第一例患者）的家庭成员，暴露于“索引患者”（所知的第一例患者）症状显现期以及较长的暴露时间都是密切接触者感染的危险因子。在隔离的起初，17.2%的H1N1检测阳性的密切接触者存在亚临床感染。与患病的家庭成员接触以及较小的年龄是感染流行性H1N1流感病毒的主要危险因子。1/6的确诊H1N1感染患者可以无症状表现。
